DDW 2017. 718. SUPERIOR ENDOSCOPIC AND DEEP REMISSION OUTCOMES IN ADULTS WITH MODERATE TO SEVERE CROHN’S DISEASE MANAGED WITH TREAT TO TARGET APPROACH VERSUS CLINICAL SYMPTOMS: DATA FROM CALM

Results:
Figure. Primary endpoint at 48 Weeks after Randomization

Conclusions: This is the first study showing that the treat to target approach leads to superior endoscopic and deep remission outcomes in CD compared with symptom-driven care.

CARE™ Faculty Perspective: This novel ‘treat to target’ concept involves monitoring patients with CD using biomarkers of inflammation, CRP, and FC, to assist in timely treatment. While this is a preliminary study, we may want to consider changing our treatment approach moving forward, as this study has demonstrated that T2T method leads to better outcomes than conventional symptom-driven care.