Topline Presentation Points
Evolution of radiation (RT) in diffuse large B-cell lymphoma (DLBCL)
An Evolving Question
- Does radiotherapy provide benefit to patients with DLBCL?
- What is the incremental benefit of RT to patients with DLBCL with immunochemotherapy?
- What is the incremental benefit of RT to patients with DLBCL with complete metabolic response?
State of the Evidence
- Most trials designed to address duration of chemotherapy, rather than benefit of RT
- Many trials not based on modern treatment practice
- Lack of chemoimmununotherapy
- Lack of functional imaging
- Old RT doses and techniques
- Incomplete local control data
- Heterogenous patient population
- What is the incremental benefit of RT in the era of chemo-immunotherapy?
Clinical Considerations
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- Bulky Disease
- In Elderly Patients
- In Young Patients
- Bulky Disease
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- Bony Disease
- Primary Mediastinal B-Cell
Lymphoma
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