CARE™ Case HL Discussion Series

Considerations for Treatment of Advanced Hodgkin Lymphoma

Hematology

21 Sep 2022

Introduction

Dr. Alison Moskowitz (Memorial Sloan Kettering Cancer Centre, NY) connects virtually with CARE™ Hematology Faculty lead, Dr. Peter Anglin (Stronach Regional Cancer Centre, ON), to discuss treatment of advanced Hodgkin Lymphoma.


Case

52-year-old woman

Presents with advanced stage cHL

  • Considered stage 4 advanced cHL
  • ECOG performance status 0-1

Variation on Case

21 vs 52-year-old woman


Supplemental Discussion

BV-AVD – efficacy and safety

Back to case of 52-year-old

  • Approach with regression of disease with small area of Deauville 4

(Refer to the notes below the video stream for timestamps that can be used to navigate video.)

Video Navigation

 

Case 1 [0:35 – 3:49]

52-year-old woman

Presents with advanced stage cHL

  • Nodular Sclerosis (NS) sub type

Adenopathy above and below diaphragm

  • Non bulky

Pulmonary nodules up to 1.7cm that also lights up on her PET scan

  • In addition PET scan lights up on several areas of bone

Considered stage 4 advanced cHL

ECOG performance status 0-1

A bit of fatigue

No other major medical issues


Variation on Case
[3:50 – 5:05]
  • 21 vs 52-year-old woman
  • Peripheral neuropathy touched on

Supplemental Discussion
[5:05 – 7:39]

Data for pregnancy suggests BV-AVD no worse than ABVD

  • Recommending fertility preservation?

GCSF is needed

  • Approach to administration?

Back to case of 52-year-old
[7:40 – 9:25]

PET2 was done. Showed regression of disease with a small area of Deauville 4 seen in one nodal group

  • How do you approach?

Concluding Remarks
[9:25 – 9:50]

 

CARE™ case discussion series is supported by Seagen Canada. [ seagen.ca ]